Children’s Hospital of Philadelphia researcher Riccardo Goddardi, Ph.D., has been named a “Young Innovator of Cellular and Molecular Bioengineering” by Cellular and Molecular Bioengineering, the ofﬁcial journal of the Biomedical Engineering Society.
Dr. Goddardi, who leads CHOP’s Bioengineering and Biomaterials lab, was recognized for his research to prevent subglottic stenosis in children, which occurs when the airway narrows due to an accumulation of scar tissue, which can happen during intubation when bacteria build up and cause chronic inﬂammation.
The condition requires invasive surgery, which comes with risks, particularly in a pediatric population. Dr. Goddardi’s lab has investigated modulating the endotracheal microbiome through the use of antimicrobial peptides to destabilize bacterial membranes and reduce inﬂammation.
Prior studies by Dr. Goddardi’s lab used in vitro models to demonstrate that incorporating AMPs into polymer-coated tubes can inhibit bacterial growth and modulate the upper-airway microbiome.
“I am honored to be recognized by Cellular and Molecular Engineering for this exciting and notable award,” Dr. Goddardi said. “We are hopeful that our airway innovation will show similar success in human trials, so that we can improve outcomes for intubated pediatric patients.”